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Paul Shashkov
Paul Shashkov

Soft Spot [EXCLUSIVE]


The soft spot on the back of the head closes by age 3 months. The larger soft spot in front can close as early as 4 months and as late as 24 months; most are closed by 18 months. Because there is no bone over the brain, these soft spots can allow us to see brain problems.




soft spot



Even though it is soft, the fontanelles still provide good brain protection for the baby. If a baby accidentally bumps their soft spot during play or normal baby activities, I would not worry about it too much, unless you can see bruising, a cut or other kinds of damage to the skin.


In an infant, the space where 2 sutures join forms a membrane-covered "soft spot" called a fontanelle (fontanel). The fontanelles allow for growth of the brain and skull during an infant's first year.


Rickets resulting from vitamin D deficiency rarely occurs in the United States but is one of the five most common childhood diseases in developing nations. Risk factors include breastfeeding without vitamin D supplementation, dark skin, and low sunlight exposure. One of the signs of rickets is craniotabes, a softened outer table of the occipital bone that buckles under pressure, producing a reaction similar to a ping-pong ball indenting and popping back out. Craniotabes is not present at birth but develops over the first few months of life. Craniotabes can occur normally in premature infants and in children younger than six months.18,24,25 Disorders associated with increased intracranial pressure that results in an abnormally large fontanel or delayed fontanel closure are discussed later in this article.


Metabolic stability is a key property to enable drugs to reach therapeutic concentrations. Microsomal clearance assays are used to dial out labile compounds in early discovery phases. However, because they do not provide any information on soft spots, the rational design of more stable compounds remains challenging. A robust soft spot identification procedure combining in silico prediction ranking using MetaSite and mass-spectrometric confirmation is described. MetaSite's first rank order predictions were experimentally confirmed for only about 55% of the compounds. For another 29% of the compounds, the second (20%) or the third (9%) rank order predictions were detected. This automatic and high-throughput reprioritization of a likely soft-spot increases the likelihood of working on the right soft spot from about 50% to more than 80%. With this information, the structure-metabolism relationships are likely to be understood faster and earlier in drug discovery.


Soft tones with a little bit of a pop of color in a matte pink ceramic vase is perfect for the one who you have a soft spot for. Due to the flower shortage, substitutions for floral selections may be made but we will always try to keep a similar look and feel to the overall arrangement.


Once your baby is born, you may notice two soft spots on their head. There is one gap at the top-front of the skull that is most noticeable. The other is smaller, toward the back of their head. Depending on your child and the size of these spots, you may not even notice them.


Metabolic stability is crucial in allowing drugs to reach therapeutic concentrations, and so highly labile compounds are often filtered out early in the discovery process using metabolic clearance assays. However, such assays do not provide information on the 'soft spots' on the compound that underlie rapid metabolism, limiting rational design to overcome this issue. A paper in the Journal of Medicinal Chemistry now describes how in silico prediction of soft spot location coupled with mass spectrometry (MS) data from high-throughout clearance assays can allow the identification of soft spots much faster and earlier in the drug discovery process.


To test this procedure, 95 drug candidates from diverse research programmes that showed high clearance in microsomal assays were investigated. Around 55% of MetaSite's predictions for the top metabolite based on the most likely soft spot were confirmed experimentally, and in another 20% of cases the top prediction was not detected but the second most likely was found. In a further 9% of cases, the third most likely metabolite was detected.


Open fontanelles are a normal finding in very young puppies. As normal puppies mature, the growth plates in their skull fuse together and the soft spots known as open fontanelles gradually reduce in size until they no longer exist. Persistent open fontanelles, however, are a common genetic condition that is seen in some small dog breeds, including Chihuahuas, Miniature Dachshunds, Pomeranians, Shih Tzus, Yorkshire Terriers, Maltese, Lhasa Apsos, and Pekingese. In these dogs, persistent open fontanelles are caused by genetic abnormalities in normal developmental skull closure. The growth plates in these dogs simply fail to fuse in a normal manner, leaving a persistent soft spot in the skull.


Open fontanelles do not typically cause problems for affected dogs. In theory, the soft spot in the skull could make your puppy more susceptible to brain injury in the event of a blow to the head. However, this is uncommon and dogs with persistent open fontanelles typically live normal, healthy lives.


Moisture is the culprit behind the soft spot on your roof, which could indicate a weak roof, and could eventually collapse. Depending on the damage and severity of the soft spot, you may even need to replace your roof entirely.


Soft spots can occur anywhere on a roof, and, often, there several at a time. They are easiest to notice in the spring when warming temperatures cause shingles and other roofing materials to expand, making dips and buckles visible.


As soon as you notice a soft spot on your roof, call in a pro. Hire a qualified roofer near you to thoroughly investigate the soft spot and make necessary emergency roof repairs or replace your roof as needed.


The roofer will remove damaged shingles and underlying plywood in the soft spot and replace it with new material. The new roofing material should keep water from coming in while allowing heat and moisture to escape without building up in your rafters, which encourages mold growth and can be a contributing cause of soft spots on your roof. They will also make sure your gutter system works correctly to efficiently route water off your roof, which is another way to prevent soft spots.


The only thing that leads us to supreme joy is to interrupt the flow of fixation and to touch the soft spot of bodhichitta. None of us should turn our backs on bodhichitta, on learning how to contact this soft spot.


Babies are born with six fontanels, which people commonly refer to as soft spots. The most noticeable are the anterior and posterior fontanels, which are, respectively, on top of the head toward the front and at the back of the skull.


There are 2 fontanelles (the space between the bones of an infant's skull where the sutures intersect) that are covered by tough membranes that protect the underlying soft tissues and brain. The fontanelles include:


Anterior fontanelle (also called soft spot). This is the junction where the 2 frontal and 2 parietal bones meet. The anterior fontanelle remains soft until about 18 months to 2 years of age. Doctors can assess if there is increased intracranial pressure by feeling the anterior fontanelle.


These tights are super comfy with fabric that is buttery soft. Great for your longest run or dress them up for a night on the town. Our customers can hardly wait to get home and put these on. Comfortable flat pocket on left leg fits a phone perfectly, which stays firmly in place for a run. Even the larger phones fit snugly in the pocket! Flat seams and printed tag prevent chafing. Made in the USA. 041b061a72


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